Modification of Synaptic-Input Clustering by Intrinsic Excitability Plasticity on Cerebellar Purkinje Cell Dendrites
نویسندگان
چکیده
منابع مشابه
Climbing fiber synaptic plasticity and modifications in Purkinje cell excitability.
The cerebellum is a brain area that is critical for the fine adjustment of motor output and for the formation of several types of motor memory. The Purkinje cell (PC) is the only type of neuron that projects out of the cerebellar cortex and, as such, is considered to be central for cerebellar processing. Purkinje cells receive two types of excitatory input: the parallel fibers rising from the g...
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Dendrites receive most of the synaptic input to the neuron, but their contribution to synaptic integration is not well understood. In this thesis I investigate synaptic integration in Purkinje neurons in cerebellar slices, focusing on the contribution of dendritic excitability using simultaneous somatic and dendritic patch-clamp recordings. I first investigated the ionic conductances underlying...
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Synaptic gain control and information storage in neural networks are mediated by alterations in synaptic transmission, such as in long-term potentiation (LTP). Here, we show using both in vitro and in vivo recordings from the rat cerebellum that tetanization protocols for the induction of LTP at parallel fiber (PF)-to-Purkinje cell synapses can also evoke increases in intrinsic excitability. Th...
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Dendrite arborization patterns are critical determinants of neuronal connectivity and integration. Planar and highly branched dendrites of the cerebellar Purkinje cell receive specific topographical projections from two major afferent pathways; a single climbing fiber axon from the inferior olive that extend along Purkinje dendrites, and parallel fiber axons of granule cells that contact vertic...
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We recently reproduced the complex electrical activity of a Purkinje cell (PC) with very different combinations of ionic channel maximum conductances, suggesting that a large parameter space is available to homeostatic mechanisms. It has been hypothesized that cytoplasmic calcium concentrations control the homeostatic activity sensors. This raises many questions for PCs since in these neurons c...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2019
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3211-18.2019